Search for: [Abstract = "on screening was performed on Agilent Technologies arrays \(Human DNA Methylation Microarray\: G4495A, Design ID, 023795\) in ten randomly selected DNA samples from the entire cohort. In the differential DNA methylation analysis, 7480 statistically significant probes were identified comparing the high LDLCH group to the low LDL\-CH group. The 190 probes related to lipid metabolism pathways were selected from this list. The selected genes have been involved in the following metabolic pathways\: metabolism and clearance of LDL and VLDL lipoproteins, regulation of lipid metabolism by PPARα, SREBP and NR1H2, metabolism and betaoxidation of fatty acids, and metabolism of TG. New epigenetically regulated genes and associated with dyslipidemia have been demonstrated\: ABCG4, ANGPTL4, AP2A2, AP2M1, AP2S1, CLTC, FGF19, FGF1R, HDLBP, LIPA, LMF1, LRP5, LSR, NR1H2 and ZDHHC8. 2. Original article\: Płatek T. et al.\: Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects. Genes \(Basel\). 2021 Feb 21\;12\(2\)\:307. The study group included overweight and obese adults \(n = 136\; 100 women and 36 men\) with a BMI of 27 to 45 kg\/m2. Patients were divided into 2 subgroups based on fasting serum levels of FGF21 \(FGF21 <213 pg \/ ml and ≥ 213 pg \/ ml\). Glucose, insulin, GIP, lipids, selected adipokines, myokines and"]

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