Search for: [Abstract = "on, complete surgical resection is not always possible, and the available forms of non\-surgical therapy also prove to be inefficient. In the fight against cancer, getting to know the mechanisms associated with the process of apoptosis gives high hopes. It is believed that a measure of the effectiveness of cancer therapy is inhibition of the proliferation process and, above all, the ability to induce apoptosis in cancer cells. Therefore, a better understanding of molecular mechanisms and signaling pathways affecting apoptosis can lead to the creation of a rational anti\-cancer strategy that will contribute to the successful treatment of cancer patients in the future. The aim of the research being the subject of the doctora\! dissertation was to determine the effect of gastrin and non\-amidated gastrin peptides on interactions between PPARy nuclear receptors and the WNT\!p\-catenin cell signaling pathway in in vitro gastrointestinal cancer models. Studies were conducted in vitro on selected cell lines \(PANC\-1, OE\-33\) originating from gastrointestinal cancer. The trophic effect of gastrin and gastrin precursors on selected cell lines was investigated using an MTT test. Experiments were also conducted to assess the effect of gastrin and gastrin precursors on interactions between PP ARy nuclear receptors and the WNT\/P\-catenin cell signaling pathway. Immunoblotting techniques were used f"]
