Search for: [Abstract = "ol derivatives \(1\(a\-c\)\-3\) with analgesic and anticonvulsant activity, derivatives of aripiprazole \(4\-7\) endowed with antipsychotic activity and derivatives of zolpidem \(8\-10\) with hypnotic and antipsychotic activity. Biotransformation studies were carried out using the in silico \(MetaSite software\) and in vitro models. Microbial model \(3 different species of filamentous fungus Cunninghamella elegans, echinulata, blakesleeana\) as well as liver microsomes model \(mouse, rat, human\) and S9 fraction were used in in vitro studies. The progress of the reaction was monitored using LC\/MS method.Based on the obtained results we were able to define the biotransformation pathways, structure of the metabolites of the tested compounds \(1\(a\-c\)\-10\) and enzymes involved in their formation. Moreover the metabolic stability, half\-life t0.5 and internal clearance Clint were determined. Interspecies differences in the rate of metabolism and biotransformation pathways were identified in case of the compound 7. Drug\-drug interactions of the major CYP450 isoenzymes were determined for compound 2, which proved to be a mixed inhibitor of CYP2D6 \(Ki = 1.701 μM\).Obtained results enabled us to determine some lipophilicity – stability dependence in case of tested compounds. Compounds 2, 3 and 8\-10 were characterized by high metabolic stability and had lipophilicity in the range of log P 2.16\-3.0, while comp"]

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