Search for: [Abstract = "of mycelium from in vitro cultures decreases \~10 times\; 5\) only Fomitopsis officinalis from in vitro cultures showed anti–cancer activity in lung cancer cell lines, while fruiting bodies were more active in skin cancer. In the next step, it was observed that at lower concentrations \(50 µL\)\: 1\) compared to lion's mane and Fomitopsis officinalis fortified with zinc or magnesium, ono–fortified Fomitopsis officinalis increased the level of induced cyclooxygenase \(COX\-2\) in mouse macrophages\; and, 2\) fortification with magnesium, caused an increase in TLR4 receptor levels. At higher concentrations \(100 µL\)\: 1\) zinc–fortified Fomitopsis officinalis increased the level of non– induced cyclooxygenase \(COX\-1\) and TLR4 receptor\; and, 2\) the effect of zinc–fortified Fomitopsis officinalis on TLR4 was enhanced in the absence of inflammation. The above profile clearly showed that the mechanism of Fomitopsis officinalis immunostimulating action is modulated by fortification\; and, that the effect of Fomitopsis officinalis on the immune response is stronger than that of lion's mane. In vivo studies on the impact of dietary supplementation with Fomitopsis officinalis on affective functions showed a positive effect on anxiety–like behavior of both mice and rats in the elevated plus maze test\; and, an increase in exploratory\/orientation behavior \(rearing\) in the open f"]
