Filters

Search for: [Abstract = "of anaemia. This doctoral dissertation is based on the cycle of 3 publications that evaluate the use of new biomarkers of ferritic management \(GDF15, sTfR and hepcidin 25\) in patients with multiple myeloma and renal failure. The relationship between markers and neoplasm advancement, anaemia, kidney failure, mortality, as well as the associations between indicators were compared and studied. 73 patients were included into the study with MM or SMM. Blood and urine samples were drawn from each patient. Biomarkers of ferritic management \(GDF15, sTfR, hepcidin 25\), as well as standard indicators of anaemia and iron deficiency, markers of MM advancement, renal failure and inflammation were assayed. After an interval of 27 months from the start of the study, laboratory test results from the last visit \(mainly markers of anaemia\) were evaluated and mortality data were completed. After evaluation of the studied markers, Serum GDF15 concentrations had the best correlations with advancement of MM \(ISS stage, as well as serum levels of FLC, urine LC, serum β2\-microglobulin and serum albumin\) and treatment response. Meanwhile, serum hepcidin 25 concentrations were additionally associated with the type of treatment prescription. Serum levels of all markers were higher in patients with anaemia\; while only GDF15 and hepcidin 25 showed correlation with HGB concentrations. Associations betwee"]

Number of results: 1

items per page

This page uses 'cookies'. More information