Search for: [Abstract = "of HBK\-15 included the investigation how HBK\-15 affected the level of phosphorylated proteins\: PKA, CaMKII, CaMKIV, RSK2, ERK1\/2, PKC, CREB, BDNF using ELISA tests, and if the antidepressantlike and procognitive activity depended on the brain derived neurotrophic factor in BDNFVal\/Met mice subjected to an unpredictable chronic mild stress procedure. HBK\-15 possessed moderate to high affinity to serotonergic 5\-HT2B and dopaminergic D1, D3, D4, and D5 receptors. Furthermore, HBK\-15 reversed recognition, emotional, and spatial, but not motor, memory impairments associated with the impaired glutamatergic neurotransmission. Moreover, the tested compound showed procognitive activity at all stages of memory formation, i.e., acquisition, consolidation, and recall. Noteworthy, the single administration of HBK\-15 was enough to produce the long\-lasting antidepressant\-like and procognitive effects \(up to 24 h\) in the animal model of depression. Moreover, HBK\-15 normalized the decreased levels of p\-CREB and BDNF in the hippocampus and in the prefrontal cortex of depressed animals, and this effect was mediated via ERK1\/2, RSK2, CaMKIV, and PKA in the prefrontal cortex. Additionally, the procognitive, but not antidepressant\-like activity, of HBK\-15 is linked to the normal activity\-dependent BDNF secretion. The obtained results suggest that HBK\-15 may become a precursor for th"]

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