Search for: [Abstract = "oes it derive from their inhibitory effect on the proinflammatory and algesic prostaglandin E2synthesis. The part of the studies concerned the mechanism of analgesic activity of LPP1, i.e. the most active compound. It was established that the primary afferent unmyelinated C\-fibres transmitting painful stimuli towards the central nervous system are the probable site of its action The influence on the peripheral or central glutamatergic system and voltage\-gated ion channels \(sodium or calcium\) is taken into account, as well. lt seems that the mechanism of LPP1's antinociceptive activity resembles the activity of co\-analgesic drugs, namely the antiepileptic or local\-anaesthetic drugs. Amide analogues of the investigated lactones seem to lose their analgesic and local anaesthetic activities. Simultaneously, the locomotor activity is affected, too \- the amide derivatives seem to increase it, which suggests their excitatory properties."]

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