Search for: [Abstract = "odies against proteins associated with obesity \(PPAR\-γ, irisin, IGFR\- 1R\), smoking\/proliferation \(AhR, EGFR\), and inflammatory markers \(IL\-17 and its’ receptor, S100A8\/MRP8\)\; antibodies delivered by Abcam, Berlin, Germany. Epidermis and dermis specimens were photographed \(x100 magnification\; EVOS AMG microscope, Bothell, Washington\). The computer program FIJI \(Fiji Is Just ImageJ\; NIH, Bethesda, USA\) and a semi\-automatic procedure \(Andy's algorithm\) were used to analyze the microscopic images. Finally, a systematic review of articles collected in the electronic databases MEDLINE, EMBASE and CENTRAL in the period of 1980\-2020 was performed by two independent investigators to identify the cases in which acne vulgaris\/acne inversa was accompanied by at least two other autoinflammatory diseases. Results\: In the first retrospective study of patients with acne vulgaris, 61% of individuals were female and 27.6 % of all patients classified as AFA. The median age in the study was 24 years, for AFA it was 32.5 years. Patients with AFA were less likely to have skin lesions on the back, and the face was the most commonly affected area. Papulopustular acne predominated in the whole population studied. In 38.7% of all subjects at least one chronic systemic disease was present, with endocrine disorders being the most common \(15.25%\), and thyroid dysfunction present in 6.21%. Endocrine disord"]
