Search for: [Abstract = "observations suggest a possible role for cFn as a coagulation modulator in asthma. ARTICLE II The lower activity of plasma Lp\-PLA2 in severe asthma compared to mild or moderate disease may be related to differences in the pathology of severe asthma phenotypes. The inverse relationship between Lp\-PLA2 and markers of inflammation as well as thrombin generation parameters suggest that Lp\-PLA2 may not be an adequate marker for assessing cardiovascular risk in patients with asthma. In severe asthma, the decrease in circulating Lp\-PLA2 activity may adversely affect the oxidative stress. ARTICLE III For the first time, increased concentration of circulating H3cit in asthma has been shown. The positive relationship between serum H3cit and TLC may suggest that circulating H3cit is related to the ongoing airway inflammation. Further research is needed to determine the relation between ETs and the increased thromboembolic risk in asthma."]

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