Search for: [Abstract = "obal network. No differences in shape and morphology of interstitial cells of Cajal were found between the study and control groups. The number of interstitial cells of Cajal was statistically significantly lower in patients in the study group as compared to the control group. Statistically significantly higher lithogenic index was also observed in the study group. The study revealed statistically significantly lower mean concentrations of glicocholic and taurocholic acids in the gallbladder bile, as compared to the control group. In summary, the number of interstitial cells of Cajal is diminished in the gallbladder of patients with cholelithiasis and there is a negative correlation between the number of ICCs and lithogenic index of bile. Taking into consideration the role of interstitial cells of Cajal in the regulation of gastrointestinal and extrahepatic bile ducts motility, it appears that a reduction of their number is an important etiopathogenetic factor of gallstone disease. Progress concerning the role of interstitial cells of Cajal in the human gallbladder may contribute to the advancement of new treatment options of disturbances of the gallbladder motility underlying cholelithiasis."]

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