Search for: [Abstract = "nificantly increased by the lack of higher education, the use of a solarium, and at least one episode of sunburn in a lifetime. Patients diagnosed with malignant melanoma were characterized by more intense photoaging of the facial skin compared to the control group, however, skin aging did not correlate with epigenetic age. Patients diagnosed invasive malignant melanoma were characterized by lower pace of aging described by PoAm parameter than patients without diagnosed malignant melanoma of the skin. Moreover, patients with melanoma located on the face were characterized by a significantly higher average value of the DNAmTL parameter \(i.e. telomere length estimated on the basis of DNA methylation\) compared to patients with melanoma diagnosed in other less sun\-exposed locations. A similar relationship was demonstrated between lentigo melanoma and superficial spreading melanoma. In this study, no direct correlation was found between methylation data, environmental factors and the occurrence of malignant melanoma of the skin. No new, previously unknown SNP variants increasing the susceptibility to malignant melanoma were identified. On the other hand, the studied population of Polish patients with malignant melanoma was characterized by a significant genetic predisposition to its development in terms of all previously discovered SNP markers characteri"]

Number of results: 1