Search for: [Abstract = "ng batteries. The average duration of diabetes was 15 years. Microarray analysis, confirmed by qRTPCR, showed significant up\-regulation of autophagy genes, mitochondrial quality, regulatory genes \(mTOR, GABARAPL2\),apoptosis, endocytoplasmic stress and inflammation in the T1DM group compared to the control group. On the other hand, down\-regulation of genes of proteolytic enzymes of lysosomes \(catepsins\) and the gene encoding the subuued of the H\+building protein \- ATPase of the lysosome membrane was observed. There were no significant differences in gene expression between patients with T1DM\+CAN and patients with T1DM\-CAN. Microarray analysis comparing patients with T1DM and the control group showed activation of genes encoding enzymes involved in DNA repair, as well as inhibition of protein expression I and III of the complex as an evidence of impaired mitochondrial function. Analysis of gene expression showed activation of pathways associated with the inflammatory process, which was confirmed by the determination of IL\-6 levels. In the group of patients with T1DM, a higher concentration of IL\-6 was observed. The observed changes in gene expression and activation of intracellular metabolic pathways give a coherent picture of the important role of oxidative stress in the course of inflammation and activation of apoptosis and neuronal degeneration, constituting"]

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