Search for: [Abstract = "ne, reboxetine, moclobemide and bupropion, but not with S\-citalopram, facilitates anti\-immobility effects of antidepressants in the forced swim test in rats. These results may suggest possibility of a synergistic interaction between a partial agonist of 5\-HT6 receptors and antidepressants which mechanism of action is connected with stimulation of dopaminergic and noradrenergic, but not serotonergic, activity.EMD 386088, after acute administration, produces specific effects characteristic of anxiolytic drugs studied in the conflict drinking Vogel and elevated plus\-maze tests in rats. Mechanism of this action seems to be directly connected with stimulation of 5\-HT6 receptors\; however, a contribution of GABAA\/benzodiazepine receptor complex should be excluded what has been confirmed by lack of GABAA receptor affinity of EMD 386088 as well as lack of functional interaction between EMD 386088 and diazepam. Moreover, antidepressant\-like activity of EMD 386088 has been presented in a higher dose than its anxiolytic\-like effects what may suggest different mechanisms involved in its actions.The obtained results increase our knowledge about the role of 5\-HT6 receptors. They constitute an important contribution to studies concerning functional importance of agonists\/partial agonists of these receptors as a basis for further, more extensive preclinical evaluation. Moreover, they confirm th"]

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