Search for: [Abstract = "nd their physicochemical properties and ADME parameters were assessed. As a result, 38 potential candidates were finally selected, 12 of which were purchased and tested for their inhibitory activity against TRPA1, PDE4B, and PDE8A in in vitro assays. The research conducted as part of the doctoral dissertation contributed to obtaining structural models of PDE8A, PDE4B, and TRPA1, pharmacophore models, and empirical models that allowed to expand knowledge about biological targets and the most important features that determine the inhibitory effect of their inhibitors\/antagonists. A great achievement was the identification of both the binding site and interaction mode of the antagonists in the TRPA1 channel. It was later confirmed by experimental structures published in the PDB database, proving the effectiveness of the used procedure. The developed strategy for the search for multitarget ligands showed also the effectiveness of the use of various molecular modeling methods in order to select new candidates for multitarget ligands. The developed strategy for searching for multi\-target ligands showed the effectiveness of using various molecular modeling methods to select ligands with confirmed inhibitory activity on single biological targets, providing a solid foundation for their further optimization towards multi\-target inhibitory activity, which in the future may improve the qu"]
