Search for: [Abstract = "nce of DNP\-BSA\-induced Treg cells on the in vitro proliferation of Tef CHS cells, adoptive transfer of CHS after the incubation of Treg and Tef cells with application of the trans\-well chambers, and inhibition of interaction between Treg and Tef cells through blockage of the CTLA\-4 molecule. These experiments showed that the mechanism of suppression requires direct contact between Treg and Tef cells and that the participation of the CTLA\-4 molecule is necessary. Moreover, immunization with DNP\-BSA does not affect production of anti\-inflammatory cytokines IL\-4, IL\-10, IL\-17E or TGF\-β.In summary, this dissertation describes a novel method of evoking immune tolerance via EC immunization of DNP\-BSA. Because of its effectiveness, ease of induction and non\-invasive protein antigen application, this immunization route may be effective for a new method of Tc1 CD8\+\-dependent contact hypersensitivity reaction therapy."]

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