Search for: [Abstract = "n that zileutone decreased on average 30% the production of leukotrienes. In addition, increased systemic biosynthesis LTE4 was documented by uLTE4 excretion measurements in the group of 38 asthmatic patients. A distinct phenotype of bronchial asthma – aspirin\-sensitive asthma, was found to correlate with elevated concentration of LTE4 in urine, by comparison with asthmatics who tolerated aspirin well.. Results obtained by the method were compared the commercial immunoenzymatic \(ELISA\) Kit. On the basis of comparison results, LC\/MS method of measurement of uLTE4 was found more accurate and precise than ELISA. LC\/MS method should be also considered as very specific, and very reliable."]

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