Search for: [Abstract = "n obese patients. Specific objectives included\: Checking if there is a DNA methylation profile associated with hypercholesterolaemia in the cohort of obese patients. Finding genes regulated by DNA methylation and associated with high levels of fibroblast growth factor 21 \(FGF21\) in obese subjects. To test if there is a specific miRNA expression profile associated with high levels of FGF21. RESEARCH METHODOLOGY AND RESULTS 1. Original article\: Płatek T. et al.\: DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia. Mol Med. 2020 Oct 7\;26\(1\)\:93. The study was conducted in a group of 137 people \(99 women and 38 men\) with BMI over 27 \(min. 27 \- max. 45 kg\/m2\) and aged 25 to 65 years. The comparison of biochemical parameters was carried out in 2 subgroups\: in the hypercholesterolaemia group with the LDL\-CH level ≥ 3,4 mmol \/ l \(n = 68\) and in the control group with the LDLCH level <3,4 mmol \/ l \(n = 69\) in the serum. The concentration of glucose, total cholesterol, HDL cholesterol, TG, insulin, leptin, adiponectin, FGF19, FGF21, GIP in the serum and total fatty acid content in the plasma were determined. The study group showed higher levels of LDLCH, total cholesterol, TG, non\-HDL cholesterol and TG\/HDL ratio compared to the control group. Whole genome DNA methylati"]

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