Search for: [Abstract = "mis \(characterized by a smaller thickness of the epidermis with positive expression of type 9 TLRs\) and a lower average percentage of lymphocytes with positive TLR9 expression compared to other patients treated with 200 mg hydroxychloroquine. Conclusions\: Our investigation justifies the recommendation for evaluating skin lesions in CLE patients using CLASI index in wide clinical practice. In case of a high CLASI score we can preliminarily identify patients with possible extracutaneous involvement. In our research work, the expression of type 7 TLR in the epidermis of CLE patients, as well as in healthy skin, was not determined. This may indicate that type 7 TLR may not play an important role in CLE development. In turn, lower expression of type 8 and 9 TLR in the epidermis, in the lymphocytic infiltrate in the dermis and lower expression of type 9 TLR in epithelial part of hair follicles in CLE patients, compared to healthy skin, positively affect the development of this disease. Our results are consistent with the SLE studies on animal and in vitro models, in which high expressions of type 8 and 9 TLR play a protective role in the development of this disease. Lower expression of type 8 and 9 TLRs in the epidermis and a lower percentage of lymphocytes in the dermis with positive expression of type 8 and 9 TLRs in skin biopsies in CLE patients may constitute an unfavorable fa"]
