Search for: [Abstract = "mic response. Obtained results suggest profound influence of diastolic function at early stage in Tgαq\*44 mice that proceed contractility impairment and cardiac decompensation in course of the development of dilated cardiomyopathy and successive exhaustion of cardiac chronotropic and inotropic reserve, with secondary impairment of coronary perfusion that leads to a typical ischemic dobutamine response., Changes in cardiac function as regards apoE\/LDLR\-\/\- mice were as follows\: accelerated heart rate, decreased end diastolic volume and decreased stroke volume. ApoE\/LDLR\-\/\- mice on LCHP diet had additionally decreased end systolic volume. Dobutamine stress test confirmed preserved contractility \(as decreased end systolic area and increased fractional area change\) and uncovered lack of slice cardiac output in apoE\/LDLR\-\/\-S and apoE\/LDLR\-\/\-LCHP mice with lack of chronotropic reserve only in the latter group. In conclusion, MRI based methodology for the assessment of cardiac function using i.p. low and high dobutamine dose stress test allowed for better characterization of cardiac function in heart failure in Tgαq\*44 mice developing dilated cardiomyopathy and apoE\/LDLR\-\/\- with advanced atherosclerosis then basal cardiac assessment neither assessment based on one dose. This experience may be well used in future experimental studies to explore cardioprotective therapies and mechanism o"]

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