Search for: [Abstract = "men\) with autoimmunologic diseases, in a stable phase of the disease \(median age, 43 years\) and 66 matched for age and sex, apparently healthy individuals were enrolled to this case\-control study. Blood samples were collected after a 14\-hour overnight fast. Total plasma Hcy \(tHcy\) levels were determined by high\-performance liquid chromatography. Serum folic acid and vitamin B12 levels were measured using a Immunolite analyzer. Antinuclear antibody \(ANA\) were assessed with indirect immunofluorescency, anticardiolipin \(ACL\) and anti\-β2 glycoprotein i \(anti\-β2GPI\) antibodies levels were measured by immunofluorescency. Serum levels of IgG antibodies against Nε\-Hcyalbumin and Nε\-Hcy\-hemoglobin were determined using an in\-house enzyme\-linked immunosorbent assay. The methylenotetrahydrofolate reductase \(MTHFR\) C677T polymorphism was determined by the polymerase chain reaction. The highest percentage of the patients were individuals with SLE \(68.5%\) \(mean disease duration, 7 years\; score in SLEDAI scale, 0 and 5\) and with APS \(43.1%\). Three patients with systemic sclerosis, 7 subjects with mixed connective tissue disease and 6 patients with dermatomyositis were also enrolled to the study. In the SLE group 34.8% of patients met criteria for APS and 55.4% of the subjects with APS, fulfilled the criteria for SLE. Patients had lower hemoglobin, HDL\-cholesterol and serum c"]

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