Search for: [Abstract = "longer\: maximum oxygen consumption at anaerobic threshold at baseline was 10.4±2.5, whereas after training 12.9±3.2 ml\/kg\/min \(p<0.05\). The duration o f exercise testing was also markedly prolonged from 378±44 to 752±85 s \(p<0.01\) and maximal workload increased from 105.6±23.4 at baseline to 143.8±31.7 Watts after training \(p<0.01\). Left ventricular parameters did not change significantly in trained patients at 6 months, although there was a trend toward better functional indices, global and regional wall motion \(ejection fraction increased from 27.4±4.7 to 31.2±5.6%, p = 0.065\; end\-diastolic volume decreased from 122.6±24.3 to 111.8±28.2 ml\/m2, p = 0.061\; segmental wall motion index decreased from 2.17±0.6 to 1.84±0.4, p = 0.056\). In the controls, exercise capacity and left ventricular parameters both on echocardiography and MR remained unchanged. MR spectroscopy of femoral skeletal muscles \('HMRS\) in trained patients showed a significant increase in Crtot\/TMA\+Crtot\+Lip \(0.18±0.06 before vs. 0.29±0.08 after training, p< 0.05\) corresponding to muscle total creatine content which plays an important role in skeletal muscle energy metabolism. There were no changes in the contents indexes for lipids and substances composed of trimethylamine groups. The controls did not show significant differences in parameters relating to biochemical composition of femoral skeletal muscles. C"]

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