Search for: [Abstract = "l patients with T1DM as part of screening annually after five years after the diagnosis of diabetes. Risk factors for the development of diabetic neuropathy include\: the duration of diabetes, lack of metabolic compensation, oxidative stress and chronic inflammatory process. Multi\-year and multicenter studies \(UKPDS and DCCT\) have shown that improving metabolic control\; through the use of intensive insulin therapy in people with diabetes\; significantly reduces the incidence of chronic complications. On the other hand, those who had their treatment intensified with a delay were observed, despite optimizing metabolic compensation through the implementation of intensive insulin therapy, were still more likely to develop chronic complications compared to the group treated with intensive insulin therapy from the beginning. This situation was well described among patients in the EDIC study, which was a continuation of the observation of the patients’ fate from the DCCT study. Based on these observations, the theory of \"metabolic memory\" of hyperglycemia in diabetic patients was put forward, which contributed to the development of research on the role of non\-genetic mechanisms in the etiopathogenesis of diseases, including diabetes and its complications. Studies of various populations and observations of monozygous twins have confirmed the role of not only genetics b"]

Number of results: 1