Search for: [Abstract = "ke properties whilst not exhibiting rewarding properties in animal models, mimics functional changes and evoke adaptations within the endocannabinoid system as classical antidepressant drugs do. \; In animal models of depression, which showed a similar phenotype, the differences in the neurochemical state were noted. In Wistar Kyoto rats, it was observed an increase of anandamide levels with increased NAPE\-PLD expression, a decrease of 2\-AG levels with increased MAGL expression in the prefrontal cortex and a decrease of anandamide levels with increased FAAH expression in the dorsal striatum. The CB1 receptors density was increased in several brain structures, which was also confirmed during study on the expression of CB receptors \(CB1\- prefrontal cortex, hippocampus, nucleus accumbens, cerebellum and CB2\- dorsal striatum, cerebellum\). Removal of the olfactory bulbs induced a decrease of anandamide levels in the prefrontal cortex, hippocampus and dorsal striatum, while an increase of anandamide levels was seen in the nucleus accumbens. The 2\-AG levels were either increased in the prefrontal cortex or decreased in the nucleus accumbens. Changes in the endocannabinoids levels in the bulbectomized rats resulted from altered expression of metabolizing enzymes. In fact, a decrease of NAPE\-PLD expression and an increase of FAAH expression was seen in the prefrontal cortex, as well as a"]

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