Search for: [Abstract = "is study was to evaluate whether there is correlation between MC1R and ASIP variants and patients' phenotypes and also if there is a link between these genes and presence of cutaneous melanoma or basal cell carcinoma. We also sought association between specific MC 1 R variants, A8818G polymorphisms and pigment phenotype and skin cancers. An additional goal of this study was to prepare quick test to analyse specific MC1R nucleotide position for allele variants that we had found to be associated with skin cancer risk in a Polish population. Patients and methods We enrolled 210 patients \(108 patients with skin melanoma and 102 patients with basal cell carcinoma\). Additionally we included into the study 30 healty individuals with RHC phenotype. Control group consisted of 93 non\-red hair patients, without history of skin cancers. Each person had assessed\: skin phototype according to Fitzpatrick scale, nevi and freckle number localized on sun\-exposed areas \(face, neck, the upper part of the back, dorsal aspect of the hands\) and also on covered areas \(buttocks, breast in women\). During the first visit we filled for each subject questionnaire containing phenotypic features data \(skin type, mole and freckle count, and also eye and hair colour\). We collected buccal swabs from every person for the purpose of genetic analysis. Samples were subjected to DNA isolation which was don"]

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