Search for: [Abstract = "is of specific anti\-inflammatory mediators. However, the role of de novo synthesis and uptake of exogenous fatty acids by endothelial cells in inflammatory conditions is not well understood and elucidated. Expanding the current knowledge could contribute to developing new anti\-inflammatory drugs and therapeutic strategies for the efficient, targeted metabolism of fatty acids in the endothelium under conditions of inflammation. Thus, it justifies undertaking research in this direction. This doctoral thesis aimed to determine whether fatty acids of the n\-6 series \(γ\-linolenic acid GLA, arachidonic acid ARA\), n\-3 series \(eicosapentaenoic acid EPA\), and lovastatin can activate the defense mechanisms of endothelial cells \(human primary umbilical vein endothelial cells, HUVEC\), activated with inflammatory factors \(lipopolysaccharide, LPS\; tumor necrosis factor\-α, TNF\-α\; and benzo\(a\)pyrene, BaP\). The above goal was achieved by analyzing the fatty acid profile of cell membranes and the expression of proteins and genes related to inflammation. Endothelial cells were incubated with arachidonic acid \(ARA, n\-6\), γ\-linolenic acid \(GLA, n\-6\) or with eicosapentaenoic acid \(EPA, n\-3\) and lovastatin \(LOVA\), and activated with inflammatory factors. Significant differences were demonstrated in the fatty acid profile of the cell membranes after incubation with ARA or EPA and incubation with LPS"]

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