Search for: [Abstract = "iofilm on their surfaces. Pathogenic bacteria are stored in biofilms, which are frequently to blame for patient infections. This doctoral dissertation examined the microbiological and physicochemical composition of poly\(vinyl chloride\) tracheostomy tubes used by patients. Then, using \"green chemistry\" \- compliant chemical techniques, an innovative type of functionalized polymer surface was created. This surface might one day be employed to create a new form of antibacterial tracheostomy tube. Objectives The major objective of this PhD thesis was to create a functionalized poly\(vinyl chloride\) surface with gentamicin nanoparticles, which can be used for producing tracheostomy tubes. With a focus on biocompatibility in contact with patient tissues, such functionalization intended to slow down or inhibit the formation of bacterial biofilms while retaining reliable performance metrics. The doctoral dissertation's precise goals have been divided up into three research strands\: 1\) evaluation of the drug resistance of isolated microorganisms to antibiotics as well as the profile of bacteria that form a biofilm on the surface of tracheostomy tubes used by tracheostomy patients. 2\) Two\-stage functionalization of the poly\(vinyl chloride\) surface\: introduction of oxygen functional groups \(using oxygen plasma\), gentamicin nanoparticles \(using the sonochemical method\), and comprehensiv"]
