Search for: [Abstract = "increase in the number of iNOS and ChATimmunopositive neurons. Uterine teloeytes are also loeated elose to nerve fibers, emphasized their putative interplay with neuronal elements. The close vicinity of TCs with nerve endings eonfinned the unique involvement of these cells in neuronal regulation in the uterus\; however, the role of the cellcell interaction with nerve fibers needs further explanation. The next issue we explored in the context of the pathogenesis of uterine fibroid was a linkage between telocytes and angiogenesis processes. Based on literature data telocytes arc eharaeterized by high sensitivity to hypoxia \(more likely than fibroblasts\). We picked up two additional specifie markers for vessels formation \(CD3 l and sFlt\-1 \(anti\-angiogenic factor\)\), and combine with immunostaining specific for TCs used before in order to reveal the correlation of telocytes with the expression of angiogenic markers. The declined number of CD34\+\/PDGFRa\+\-cells in leiomyoma was accompanied by a prevalence of collagen deposits, poor vascularization, a high immunopositivity of the myometrium to sflt\-1 \(anti\-angiogenic factor\). We concluded that uterine telocytes, sensitive for angiogenic factors \(PDGF and VEGF\) and ischemia, have been declined and even disappeared during fibrosis and are mainly located in close vicinity of blood vessels. They might play a role in the angiogenic response t"]

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