Search for: [Abstract = "ic secretion. In the course of further study it was demonstrated that curcumin exhibits gastroprotective effects in an experimental model of acute ethanol\- and stress\-induced injury, and that these effects are accompanied by an increase in gastric blood flow and in secretion of gastrin.Curcumin reduces the expression of mRNA inflammatory factors, and increase of mRNA expression of anti\-inflammatory and antioxidant factors in gastric mucosa exposed to the damaging effects of ethanol or stress. In the course of the study it has been demonstrated that both PG synthesized by COX\-1 and COX\-2 take part in the gastroprotective mechanisms of curcumin. In the course of further study an evaluation was made of the involvement of endogenous NO in the mechanisms of the gastroprotective effects of curcumin. In the final stage of the study an examination was made of the involvement of capsaicin\-sensitive visceral\-sensory fibres in the mechanisms of the protective effects of curcumin.In conclusion, the intragastric application of curcumin inhibits both basal gastric acid secretion and the secretion stimulated by histamine or pentagastrin. Curcumin exhibits dose\-dependent gastroprotective, hyperemic and gastrin secretion\-increasing effect in a model of acute experimental ulceration of the gastric mucosa caused by administration of 75% ethanol or under conditions that cause systemic stress. Intr"]

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