Search for: [Abstract = "ic ischemia followed by reperfusion of the gland. Obestatin \(4, 8 or 16 nmol\/kg\/dose\) was administered intraperitoneally twice\: 0.5 h before exposure to ischemia, and 3 h after the first injection. The effect of obestatin on the course of necrotizing pancreatitis was assessed after 6\-h reperfusion and included histological, functional, and biochemical analyses. In the second series of the study AP was induced by pancreatic ischemia followed by reperfusion of the pancreas. Obestatin \(8 nmol\/kg\/dose\) was administered intraperitoneally twice a day, starting 24 hours after the beginning of reperfusion. The effect of obestatin in the course of necrotizing pancreatitis was assessed between 2 and 14 days, and included histological, functional, and biochemical analyses. In the third series of the study AP was induced by cerulein given intraperitoneally 5 times with 1h intervals at the dose of 50 μg\/kg\/dose. Obestatin was administered twice a day at the dose of 8 nmol\/kg\/dose, starting with the first dose 24 h after the last injection of cerulein. Severity of acute pancreatitis was examined at 0 h or 1, 2, 3, 5, 7 and 10 days after the last injection of cerulein. Results and conclusions Administration of obestatin inhibited the development of ischemia\/reperfusion\-induced AP. This observation indicated that the protective effect of obestatin in the pancreas is universal and independent o"]

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