Search for: [Abstract = "hile a decrease of CB1 receptors density in the dorsal striatum after IMI and ESC administration and in the nucleus accumbens after chronic IMI treatment was reported. These changes were confirmed in the study on expression of CB1 receptors. Additionally, for the first time changes in expression of CB2 receptors after antidepressant drugs\/compounds were reported, an increase of expression of CB2 receptors was observed in the cortical structures and hippocampus after administration of ESC, TIA or NAC, as well as a decrease of this expression was noted in the dorsal striatum, nucleus accumbens and cerebellum after IMI administration. The effects of antidepressant drugs\/compounds on the endocannabinoid system seem to be short\-lived, endocannabinoids levels returned to control \(vehicle\) levels after a 10\-day washout period of IMI, TIA, NAC and URB597. Raised levels of these neurotransmitters were maintained in the hippocampus and dorsal striatum even after a 10\-day washout period of ESC.Specificity of effects occurring after antidepressant drugs\/compounds were related to activity of CB1 and CB2 receptors. Only the mechanism of changes in the levels of 2\-AG in the dorsal striatum after ESC treatment was not related to CB1 receptors, while changes in the levels of this neurotransmitter in the frontal cortex and hippocampus \(after administration of IMI, TIA or ESC, respectively\), and"]

Number of results: 1