Search for: [Abstract = "hich the effect of B\-cyclodextrine on the stability of the antibiotics examined was the largest \(i.e. the differences between concentrations of the ingredient determined without and with the presence of B\-cyclodextrine were the largest\). It was found that the difference in concentrations of the antibiotics examined without and with the presence of B\-cyclodextrine is the largest in the case of 1\-acetoxyethyl ester of cefuroxime in HCI concentration of 0.1 mol\/L, cefaclor in HCI concentration of 0.5 mol\/L, and ceftriaxone in 1 mol\/L HCI. While examining stability of 1\-acetoxyethyl ester of cefuroxime, it was demonstrated that decomposition depends on incubation temperature. At 40°C, one product is formed, identified as cefuroxime, while at 50°C and 60°C \- there are two additional products, one of which was identified as 2\-\[amino\(carboxyl\)methyl\]\-5\-\(hydroxymethyl \)\-3 ,6\-dihydro\-2H\-I ,3\-thiazine\-4\-carboxy lic acid. The structure of the next hydrolysis product failed to be validated with the 1H NMR method. The process of hydrolytic decomposition of cefaclor in acidic environment leads to formation of always two products, regardless of the incubation temperature. It was found that one of the hydrolysis products can be 7\-amino\-3\-chloro\-8\-oxo\-5\-thia\-I\-azabiciclo\[4.2.0\]oct\-2\-eno\-2\-carboxylic acid, the other one being the remainder of phenyloglycine. In the case of ceftriaxone, we"]

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