Search for: [Abstract = "g the the first part of the study, a very rare case of invasive pulmonary aspergillosis \(IPA\) caused by A. niger from in the oral cavity of a mechanically ventilated COVID\-19 patient was identified. A. niger was detected in the gingival pocket was diagnosed earlier than in the bronchial lavage fluid.. Analysis of patients with DMI showed that they had good metabolic control of diabetes \(mean HbA1c% 6,97 ± 0,95%\). The oral health status in this group of patients was good as indicated by the OHAT scores. The oral microbiota in this group of patients was diverse across all investigated sampling sites and characteristics of each niche with detailed information on all identified bacteria and fungi species were presented. In this doctoral thesis a bidirectional relationship between the oral health status and oral microbiota with systemic diseases was demonstrated. The acquired results suggest, that in patients with a severe course of COVID\-19 who are hospitalized in an ICU, improper oral hygiene leading to poor oral health status and mechanical ventilation, can facilitate the passage of microorganisms from the oral cavity to lower respiratory tract, leading to pneumonia. Ensuring effective oral hygiene is crucial in sustaining the balance of oral bacterio\- and mycobiota in patients with severe COVID\-19. The results of oral microbiota analysis can suppl"]
