Search for: [Abstract = "functioning, women with low physical functioning had more frequentdiabetes \(OR=2.63\; 95%CI\: 2.01\-3.44\), obesity \(OR=2.22\;95%CI\: 1.86\-2.64\), hypertension \(OR=2.05\; 95%CI\: 1.73\-2.42\), lowphysical activity \(OR=1.92\; 95%CI\: 1.65\-2.24\), more frequent wereoverweight \(OR=1.31\; 95%CI\: 1.12\-1.53\) and smokers \(OR=1.21\;95%CI\: 1.04\-1.41\). After adjustment for age, the highest risk of CVDincidence was observed in participants with low physical functioning\(HR=1.97\; 95%CI\: 1.35\-2.89 in men and HR=3.02\; 95%CI\: 1.74\-5.24in women\). Further adjustment for education, marital status, physicalactivity, history of chronic diseases and CVD risk factors attenuatedrisk partially, but the relationship remained significant \(HR=1.57\;95%CI\: 1.00\-2.45 in men and HR=2.07\; 95%CI\: 1.04\-4.10 in women\).After adjustment for age, the highest risk of CVD death was observedin participants with low physical functioning \(HR=7.43\; 95%CI\: 3.82\-14.46 in men and HR=4.06\; 95%CI\: 1.79\-9.22 in women\) in allparticipants, as well as in participants free of CVD at baseline\(HR=4.55\; 95%CI\: 2.15\-9.63 in men and HR=3.73\; 95%CI\: 1.51\-9.20in women\). Further adjustment for education, marital status, physicalactivity, history of chronic diseases \(included CVD\) and CVD riskfactors in all participants attenuated risk partially in men \(HR=3.86\;95%CI\: 1.75\-8.49\) but in women the relationship between physicalfunctioning and CVD mortality became insignificant \(HR=2.25\;95%CI\: 0.78\-6.43\). Similarly, in participants free of CVD at baseline,adjustment for education, marital status, physical activity, historyof chronic diseases \(other than CVD\) and CVD risk factors attenuatedrisk partially in men \(HR=3.34\; 95%CI\: 1.37\-8.12\) but in women therelationship has become insignificant \(HR=1.97\; 95%CI\: 0.65\-5.94\).In conclusion, both in men and in women, low physical functioningwas related with more frequent prevalence of hypertension, diabetes,smoking, low physical activity and obesity. Men with low physicalfunctioning had higher risk of incident CVD and CVD deathcompared to men with very good physical functioning. Therelationship was independent of classical CVD risk factors. Womenwith low physical functioning had higher risk of incident CVDcompared to women with very good physical functioning.The relationship was independent of classical CVD risk factors. Inwomen, prevalence of CVD risk factors explained the relationshipbetween physical functioning and CVD mortality. Low physicalfunctioning was associated with CVD risk factors as well as CVDincidence and mortality, and method used for assessment of physicalfunctioning may be a simple screening tool for identifying personswith low physical functioning."]

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