Search for: [Abstract = "for R151C, R160W variants. Obtained results confirm previous observations that the presence of MC1R gene mutations independently increases melanoma risk\; we did not show modifying influence of the eye colour, skin phototype, hair colour, presence of nevi or freckles on this correlation. \"Major function\" mutations carriers had 3. 7 fold increase in melanoma risk compared to subjects without R mutations. This result indicates strong genetical predisposition mediated via MC1R gene on melanoma risk in Polish population. MC1R polymorphisms evaluation may play an important role in prophylactic screening examinations. According to our results earring R151C or R160W variant allele is associated with a fourand twofold increase in skin melanoma risk\; therefore detecting one of these variants using minisequencing method may be of a high diagnostic value. The quick diagnostic test prepared in this study is very sensitive, trustworthy, economical and may be used in wide prophylactic studies. We did not detect correlation between ASIP genotypes \(AJA, AJG, G\/G\) and melanoma risk. ASIP variants did not modify correlation between MC1R variants and melanoma risk. \"Major function\" \-R variant carriers in MC1 R gene, 3.3 times more frequently had basal cell carcinoma compared to subjects without these mutations. Eye and hair colour, skin phototype, presence of freckles or nevi did not"]

Number of results: 1