Search for: [Abstract = "f this species are both dietary and medicinal because of the presence of β\-glucans \(e.g. lentinan\), phenolic acids, lovastatin, ergothioneine, or bioelements and vitamins. The content of the above\-mentioned biologically active metabolites, as well as the ability of mycelium from in vitro cultures to accumulate bioelements, which play a key role as anti\-inflammatory factors, determined the choice of this species for research in the presented study. Based on the results of the expression of proteins obtained with the Western blot technique\: cyclooxygenase 2 \(COX\-2\), nuclear factor Nrf2, or the peroxisome proliferator\-activated receptor γ \(PPARγ\), it was shown that the addition of Zn, Cu or Se compounds may enhance the anti\-inflammatory properties of mycelium extracts L. edodes. Selenium turned out to be the element most strongly enhancing the anti\-inflammatory effect of L. edodes mycelium. Due to the lack of this element in the soils of central Europe, which results in its deficiency in livestock, and thus in the human body, subsequent studies determined the optimal concentration of selenium addition to obtain a mushroom\-selenium preparation with an immunostimulating effect. The safety of the preparation was determined using cytotoxicity tests \(MTT and LDH\). In the calves fed with Se\-enriched L. edodes mycelium selected for the experiment, this element was determined at the physi"]

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