Search for: [Abstract = "example from Aminoglycosides group\: Netylmicin 74,2% and Tobramicin 73,1%, which revealed high activity in vitro. Obtained result of pharmacokinetics and pharmacodynamics \(PK\/PD\) investigation, which was conducted among 10 patients, showed, that in order to apply the appropriate dose of antibiotic \(chemotherapeutic\) in the HAP therapy, it is relevant to monitor the concentration of antimicrobial drug in serum of patient blood. In research observed too high doses of Carbapenems which were applied in the group of 3 patients. It was probably result of renal failure, excretion defect and accumulation of drug in the organism. Among 4 patients were applied too low doses of antibiotics. There weren’t achieved the optimal parameters PK\/PD. In one patient was changed an applied antimicrobial drug to Piperacillin\/ Tazobactam because there wasn’t reported desirable microbiological and therapeutical effect of therapy. In the genetic investigation the high genetic diversity was showed in the group of 10 P. aeruginosa strains, which were aetiologic agents of pneumonia in different patients. Investigated isolations probably came from the one hospital strain which has undergone evolutionary divergence phenomenon in time, as a result of medicine application and changing conditions of the hospital environment. However, there was observed higher degree of homology between A. baumannii isolates \(1"]
