Search for: [Abstract = "erythematosus was undertaken. Aims\: a. Assessment of strength of type 7, 8 and 9 TLRs expression in the epidermis and within lymphocytes of the inflammatory infiltrate, expressed on a 3\-point scale. b. Assessment of thickness of the epidermis and thickness of the epithelial part of hair follicles with a positive immunohistochemical reaction for type 7, 8, 9 TLRs. c. Assessment of the percentage of lymphocytes with a positive immunohistochemical reaction for TLRs 7, 8, 9. d. Analysis of a correlation between the level of expression of type 7, 8, 9 Toll\-like receptors and the response to treatment with hydroxychloroquine, measured by the percentage reduction in CLASI index. e. Analysis of a correlation between the degree of disease severity assessed in the CLASI scale and selected laboratory and clinical parameters. Methods\: Sixty\-six patients with cutaneous lupus erythematosus \(SCLE and DLE\) who are patients of the Dermatology Clinic of the University Hospital in Krakow were enrolled. The control group was consisted of 4 healthy individuals from whom a biopsy of healthy skin, not exposed to UV radiation, was collected from the buttock area. Each patient enrolled in the study had a skin biopsy prior to the initiation of systemic immunomodulatory and immunosuppressive therapy, including hydroxychloroquine therapy. Then, expression of type 7, 8, 9 TLRs in skin biopsies in th"]
