Search for: [Abstract = "ers were significantly more frequent in women with AFA than in other patients, while cutaneous features of hyperandrogenism were less frequent in AFA. Furthermore, in the immunohistochemical examination of the skin probes of HS patients, peptides associated with obesity showed differential expression between groups, whereas peptides associated with smoking were not significantly different between OS and NN. EGFR manifested stronger in the NN than OS group. IL\-17R showed greater immunoreactivity in the OS group, whereas S100A8 staining showed a substantial, increased expression in all subjects. Finally, in our third study a systematic literature review identified 64 articles on syndromic HS. The articles included those regarding already well\-defined syndromes as well as new, previously undescribed constellations of symptoms, for instance with ocular involvement. Cutaneous symptoms, including HS, usually preceded symptoms from other organs, and they proved resistant to conventional therapy in a significant proportion of patients. Conclusions\: The results of the study indicate that metabolic disorders \(obesity\) play a pivotal role in the pathogenesis of acne inversa, while the impact of smoking is less prominent. A special subgroup of women with acne present >25 years of age was identified, which is a growing health problem nowadays\: in this population acne may constitute an isol"]
