Search for: [Abstract = "ed into duodenal lumen \(intraduodenally i.d.\) on pancreatic exocrine secretion under basal conditions or following the stimulation of this secretion with diversion of pancreato\-biliary juice. I would also like to examine the involvement of CCK, sensory nerves vagal nerves and entero\-pancreatic reflexes in the effects of luminally administered melatonin, L\- tryptohan, leptin or ghrelin on pancreatic exocrine secretory function. The studies were performed on anesthetized rats with pancreto\-biliary fistulas. The animals were surgically equipped with silicone catheters, one of them was inserted into pancreto\-biliary duct and used to the collection of pancreatic secretion in 15 minutes aliquots , the other one \- into duodenum for the purpose of reinfusion pancreto\- biliary juice \(previously collected\) into the gut lumen. The examined substances \(melatonin, L\-tryptophan, leptin ghrelin\) were dissolved in 0.5 ml of saline and administered intraduodenally as a bolus. To evaluate the role of vagal nerves in the pancreatic secretory effects melatonin, L\-tryptophan, leptin or ghrelin in the rats the subdiaphragmatic vagotomy was performed tor 7 days before experiments. The involvement of sensory nerves in the effects of examined substances on the basal pancreatic enzyme secretion was studied in the lats with sensory nerves deactivated with capsaicin. Deactivation of sensory fibers was a"]

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