Search for: [Abstract = "d not change \(p=0.12\), similarly to the control group \(p=0.61\). After the first 3 months of oral appliance treatment, a 43% decrease of IL\-10 concentrations close to the level of statistical significance was found \(p=0.06\) without further reduction after the next 3 months \(p=0.66\). The concentration of PAI\-1 during a 6\-month treatment with oral appliance was reduced to 19.89 ng\/ml \(29.6 %\) \(p=0.008\). Interestingly, the concentration of TAFIa also decreased in the OSA group during oral appliance treatment from 81.23 pmol\/l to 43.43 after 6 months \(p=0.001\), which accounts for 50.5% of the initial concentration, and this fall was substantial already after the first 3 months \(p=0.029\). A significant correlation between IL\-1ß and PAI\-1 concentrations at the 3 time points was found. Similarly there was an association of TAFIa concentration and AHI as well as the oxygen saturation lower than 90%. Other markers of inflammation, including CRP, and those of hemostasis, including thrombin generation, remained unaltered during 6 months of oral appliance use. Summarizing, this study confirms the effectiveness of treatment with oral appliances in the moderate OSA, which is corraborated by a marked improvement of the polisomnographic parameters. Importantly, for the first time it has been shown that the treatment with oral appliances in moderate OSA patients decreases the concentrations of I"]

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