Search for: [Abstract = "d evaluate its absolute bioavailability. The results of the research work showed that factors such as hydroxyapatite microstructure, reflected by its porosity which is dependent on the biomaterial composition and preparation procedure, and the method of loading the drug into a matrix \(tablets, hollow cylinders\), significantly affect drug release profile. Moreover, drug’s solubility and degree of ionization as well as the presence of protein in the matrix are yet another important parameters controlling the rate and amount of released drug. In a heterogenous system \(hollow cylinder\) drug\-release pattern from the tested hydroxyapatite biomaterials generally followed zero\-order kinetics, whereas in a homogenous system \(tablet\) it obeyed Fick’s law of diffusion and followed the Higuchi equation. In conclusion, both in vitro and in vivo petoxifylline release profiles from the tested hydroxyapatite implants appear to be beneficial and suggest that these materials may serve as potential drug delivery systems."]

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