Search for: [Abstract = "d a significantly lower proportion of HbA1c among patients without neuropathy, and CSII was a more common therapeutic model in this group. Analysis of the level of specific DNA methylation showed significant differences in the regions of genes responsible for the regeneration of nerve fibers \(NINJ2\) and the functioning of nerve cells \(BRSK2, CLDN4\). Compared to patients without diagnosed cardiovascular neuropathy, CAN\+ patients had significantly higher NINJ2 methylation levels and lower BRSK2 and CLDN4 5'UTR methylation levels. QRT\-PCR confirmed weaker expression of NINJ2 and CLDN4 in CAN\+ patients. A different DNA methylation profile of genes responsible for the development and regeneration of nerve fibers in patients with T1DM and autonomic neuropathy of the cardiovascular system seems to confirm the role of epigenetic mechanisms involved in \"metabolic memory\", promoting the development of autonomic neuropathy, a chronic complication of type 1 diabetes. Due to the specificity of nerve tissue, further research on tissue cultures is advisable to better understand the subject of genes associated with neurons degeneration and regeneration \(RAGs\)."]

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