Search for: [Abstract = "cytokines were measured and compared in the high FGF21 group \(n = 68\) to the low FGF21 \(n = 68\) group in the serum. The group with high circulating FGF21 levels had a higher WHR, increased levels of fasting insulin and HOMA\-IR, free fatty acids and triglycerides. Increased levels of GIP as well as markers of liver damage \(ALT, GGT\) were also found. Obese patients with high FGF21 had elevated levels of vascular endothelial growth factor \(VEGF\), monocyte chemotactic protein \(MCP1\), and decreased levels of adiponectin. Analysis of DNA methylation was performed on methylation microarrays \(Human DNA Methylation Microarray\: G4495A, Agilent Technologies\) and miRNA expression on TLDA microarrays \(TaqMan® Array Human MicroRNA A \+ B Cards Set v3.0, Thermo Scientific\) in leukocytes of randomly selected samples \(8 from each group\). We identified 11198 differentially methylated CpG probes \(p <0,01\) in the high FGF21 group compared to the low FGF21 group. The identified genes were associated with glucose transport, insulin secretion and signaling, lipid transport and cellular metabolism, response to nutrient levels, thermogenesis, browning of adipose tissue and bone mineralization. We showed a statistically significant differences in the expression of four miRNAs in peripheral blood leukocytes that were associated with high serum levels of F"]

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