Search for: [Abstract = "cription factors\: MITF, NFkB, AP\-1, Notch, CREB, Ets\-1, β\-katenine\/LEF\/TCF, STAT, RAR and RXR affect melanoma progression. These transcription factors influence cell proliferative abilities, invasivnes and metastatic potential. Retinoid receptors RAR and RXR are co\-receptors of PPAR transcription factors. Unlike retinoid receptors, that are relatively well characterized in the skin, melanocytes and melanoma, the role of PPAR in melanoma progression is much less known. What is more, the published data are often contradictory. The aim of this study was to determine whether PPAR ligands influence proliferation, apoptosis and expression of selected proteins that are significant for malignant melanoma progression, migration and angiogenesis. In order to verify the working hypothesis of anticancer activity of PPAR, mRNA and protein expression for three receptors\: PPAR α, β\/δ, γ in four melanoma cell lines derived from different stages of its development was examined. The effect of different ligands on transcriptional activity of PPAR and the ability to bind active factors to peroxisome proliferator response element, PPRE was also analyzed. The influence of synthetic ligands of individual PPAR on melanoma cells proliferation, and expression of cell cycle regulatory proteins, such as p21, cyclin D1, c\-Myc, NFkB was determined. In addition, the effect of PPAR ligands on the secretion"]

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