Search for: [Abstract = "ces antipsychotic, antidepressant and anxiolytic activity. Among analogs of 2,3\-dichlorophenylpiperazine, PZ\-508 is a potential antipsychotic compound with an antidepressant component, and two analogs PZ\-549 and PZ\-599 evoke antidepressant and anxiolytic effects. The study has also been an attempt to determine the mechanism of action produced by selected, new derivatives. The obtained data show a positive interaction of the tested compounds with antidepressants which affect transmission by strengthening noradrenergic and\/or serotoninergic one i.e. imipramine and S\-citalopram and the anxiolytic drug  diazepam. The participation of 5\-HT1A receptors in the antidepressant and anxiolytic activity of PZ\-549 and PZ\-599 has been excluded. \; The results of pharmacological experiments with two series of newly synthesized compounds belonging to a widely studied group of azinesulfonamide derivatives of long\-chain arylpiperazines, confirm the desirability of searching for multireceptor profile compounds as potential psychotropic drugs, which can be used to treat mental illnesses. This study meets the contemporary trends in the search for new, more effective neuroleptics with no latency time, since currently available drugs are not effective or safe satisfactorily. The most active compounds, selected in these studies, will be used for further research to broaden the knowledge of their centr"]

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