Szukana fraza: [Abstrakt = "ce, favorable mechanical properties, faster disintegration time \(<20 s\) and higher drug amount released \(>95% after 15 min\) as compared to films containing raw aripiprazole. Based on the results of the analysis, it was shown that the ODF films containing PVA as the film\-forming polymer, glycerol as a plasticizer \(15%\) and solid dispersion were characterized by the best properties among all tested cast films. The ODF films prepared with the electrospinning method, using PVA as the film\-forming polymer, were characterized by good mechanical properties and the shortest disintegration time \(1 s\) among all tested formulations. Moreover, the increased surface area and partial amorphization of the drug substance had a positive effect on the drug substance release profile. The mechanical properties of the PVA\-based ODF films obtained by 3D printing were similar to the films produced by the casting method. However, their disintegration time was more than two times longer. What is more, the aripiprazole in printed films was in an amorphous form which positively influenced its dissolution profile. Stability studies of the ODF films packed into ALU \/ ALU sachets in a climate chamber of 25℃\/60%RH showed changes in the amount of aripiprazole released. The results of the tests carried out in the conditions of 40℃\/75% RH indicated that the stability studies should be performed using a more"]

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