Search for: [Abstract = "cation, a group of 164 patients was analysed, in whom no symptoms of hypersensitivity to the tested drug were found in the oral challenge test \(OCT\). In follow\-up, 9.2% of those who were re\-exposed experienced symptoms of drug hypersensitivity \(negative predictive value OCT 90.8%\). Hypersensitivity symptoms that occurred after re\-exposure were mild. The analysis of excipients present in generic drugs that caused symptoms after re\-exposure \(acetylsalicylic acid, paracetamol, meloxicam, and diclofenac\) showed that they may be one of the potential causes of false\-negative OCT. 33 patients in the study group avoided re\-exposure to the drug, despite the negative results of the challenge tests. Our results showed that oral challenges with non\-opioid analgesics have high diagnostic value. Patients should be advised to use exactly the same medicinal product that was used for their negative OCT in their daily lives due to variability in the formulation of excipients in generics containing the same active substance. Since many patients avoid re\-exposure to a given drug, despite the negative test result, another very important conclusion is the need to properly educate patients about the goals and results of the diagnostics. The chapter of the monograph constituting the final part of the series of publications summarizes key information on the mechanisms, symptoms and management of para"]
