Search for: [Abstract = "c sclerosis had similar serum levels of VCAM\-1 and thrombomodulin as compared to healthy individuals, however, the ANCOVA analysis revealed that levels of thrombomodulin were increased in the systemic sclerosis group \(p=0.03\). In ultrasonograpy, GPA patients had 48.9% decrease in FMD% \(p<0.001\) and similar IMT and aortic stiffness. The EGPA group was characterized by a 38.8% decrease in FMD% \(p<0.001\) without any statistical differences in IMT. Patients with systemic sclerosis were characterized by 45% lower FMD% and 13% higher IMT, as compared to the control group \(p<0.01\).The values of FMD%, IMT, VCAM\-1 and thrombomodulin were mainly associated with CRP, IL\-6, creatinine and urea concentrations. Conclusions\: The patients with evaluated connective tissue diseases present with endothelial injury which is the result of chronic inflammation process, an influence of antibodies and organ damages as a consequence of the disease."]

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