Search for: [Abstract = "c area \(EDA\), end\-systolic area \(ESA\), ejection ratio \(ER\), filling ratio \(FR\), fractional area change \(FAC\). In addition to the study on Tgαq\*44 mice, the echocardiography examinations in short parasternal and long apical axis were also performed in patient with heart failure. The following parameters were assessed \: EDA, ESA, FAC, FR, ER. The results of all these animals studies indicated that ACE inhibition in Tgαq\*44 mice was more effective in the advanced and end \-stage of heart failure but not in early stage of this pathology. In particular ACE inhibitor monotherapy \(perindopril\) in advanced stage of heart failure, resulted the decrease in ESA and increase in FAC without influence on others LV parameters. Monotherapy with ARA \(alodosterone\) was more effective than combined therapy ACE inhibitor \(perindopril\) and ARA \(aldosterone\). In the end \- stage of heart failure combined therapy essentially inhibited the dilatation of LV and progression of diastolic and systolic impairment, as compared with the control group. The echocardiography examinations \(based on actual recommendations\) of patients with systolic and diastolic dysfunction were also performed. The echocardiography examinations revealed that systolic and diastolic parameters in long axis and reflected the impairment of ER and FR which were estimated in short parasternal axis, indicating that systolic and diastolic"]
