Search for: [Abstract = "ation of interleukin\-1β in oral mucosa. Also, in rats with induction of oral mucosa ulcers, hypophysectomy failed to affect the healing rate of these ulcers or blood flow, cell proliferation or concentration of interleukin\-1β in gingival and lingual mucosa. On the other hand, administration of ghrelin was without any effect on healing rate and other parameters in oral mucosa in hypophysectomized rats. In salivary\- and pituitary\-intact rats, as well as in sialoadenectomized rats with intact pituitary, therapeutic effect of ghrelin in the healing of oral mucosa ulcers was well\-correlated with the ghrelin\-induced increase in serum concentration of growth hormone and IGF\-1. Hypophysectomy increased serum concentration of endogenous ghrelin, but serum concentration of growth hormone was reduced below limit of detection, whereas IGF\-1 was decreased by 90%. Administration of exogenous ghrelin failed to affect serum concentration of growth hormone or IGF\-1 in hypophysectomized rats., Conclusions\: Treatment with ghrelin accelerates healing of chronic ulcers gingival and lingual mucosa in rat with a primary normal oral mucosa, as well as in rats with a reduction of mucosa cell proliferation evoked by sialoadenectomy. This therapeutic effect of ghrelin is mediated by the release of endogenous growth hormone and IGF\-1. Hypophysectomy abolishes stimulatory effect of ghrelin on the release o"]

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